On Sega Genesis and Sega CD port, the accuracy for each stage corresponds to the given rank: If the player has killed innocents on any stage, they will either maintain their rank or will be demoted, although the ranks do not go below Posse. When the game begins, the player's rank is Posse, and after each stage the player will be promoted, provided they have not killed any innocents. The ranks are: Posse, Deputy, Sheriff, Deputy Marshal and U.S. There are different ranks that the player can attain, depending on how well the player performs. If a player is shot while in possession of one of those acquired weapons, the weapon is lost and the player will return to the six-shooter. The Gatling guns and cannons can each be used only once but the other four weapons can be reloaded the same way as the six-shooter. 50 caliber Sharps, rifles, double rigs, shotguns, Gatling guns, and cannons. Additional weaponry can be found throughout the game that will give the player better firepower. To reload, the player must aim the light gun away from the screen and pull the trigger. The player's gun (a six-shooter) can carry up to six bullets. Just like the original game, a dip switch setting in the arcade version allows operators to let players progress through the stages in a linear fashion ('arcade mode') or select individual stages ('street mode'), including the between level target practice stages. Each stage features a boss that must be killed in order to complete the stage (though a unique case happened in the third stage where the boss battle is in the form of a dueling mini-game). During each stage, the player must shoot the armed outlaws without harming any innocent townsfolk or fellow lawmen. Lethal Enforcers 2 has five stages: 'The Bank Robbery', 'The Stage-Holdup', 'Saloon Showdown', 'The Train Robbery', and 'The Hide-Out'. The game overs when all life units are gone, but continued play is available. Every time the player, an innocent civilian or lawman is shot, one life unit will be lost. Life units are also awarded based on how many points the player scores while playing the game. In the arcade version, more can be purchased by inserting additional coins.

At the beginning of the game, three to five life units are available. In this game, the goal is to shoot outlaws in order to eradicate crime from a stereotypical town in the American West of 1873.

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